RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Sftpc
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo
Year
2015
Function
Decreased expression of SFTPC by TGF-B1 treatment was restored by TSA via hyperacetylation of histone H4 in the promoter region. TSA partially attenuated pulmonary fibrosis and increased Sftpc mRNA in ATII.